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A structural road map to unveil basal body composition and assembly

2012-02-01Journal article Open access
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dc.contributor.authorJana, Swadhin C
dc.contributor.authorMachado, Pedro
dc.contributor.authorBettencourt-Dias, Mónica
dc.date.accessioned2018-02-08T17:30:05Z
dc.date.available2018-02-08T17:30:05Z
dc.date.issued2012-02-01
dc.descriptionThe deposited article is a post-print version and has been submitted to peer review.pt_PT
dc.descriptionThis publication hasn't any creative commons license associated.pt_PT
dc.descriptionThere is no public supplementary material available.pt_PT
dc.description.abstractThe Basal Body (BB) acts as the template for the axoneme, the microtubule‐basedstructure of cilia and flagella. Although several proteins were recently implicatedin both centriole and BB assembly and function, their molecular mechanisms are stillpoorly characterized. In this issue of The EMBO journal, Li and coworkersdescribe for the first time the near‐native structure of the BB at 33 Åresolution obtained by Cryo‐Electron Microscopy analysis of wild‐type (WT) isolatedChlamydomonas BBs. They identified several uncharacterized non‐tubulinstructures and variations along the length of the BB, which likely reflect thebinding and function of numerous macromolecular complexes. These complexes areexpected to define BB intrinsic properties, such as its characteristic structure andstability. Similarly to the high‐resolution structures of ribosome and nuclear porecomplexes, this study will undoubtedly contribute towards the future analysis ofcentriole and BB biogenesis, maintenance and function.pt_PT
dc.description.sponsorshipFundação para a Ciência e Tecnologia grant: (PTDC/BIA‐BCM/105602/2008); EMBO Installation Grant; Instituto Gulbenkian de Ciência; ERC grant(261344—CentriolStructNumber).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSwadhin C Jana, Pedro Machado, Mónica Bettencourt‐Dias (2012). A structural road map to unveil basal body composition and assembly. EMBO J. 31(3):519-21. DOI 10.1038/emboj.2011.474pt_PT
dc.identifier.doi10.1038/emboj.2011.474pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/834
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherEMBO Presspt_PT
dc.relationControl of Centriole Structure And Number
dc.relation.publisherversionhttp://emboj.embopress.org/content/31/3/519pt_PT
dc.subjectAnimalspt_PT
dc.subjectCiliapt_PT
dc.subjectMicrotubulespt_PT
dc.subjectBasal Bodypt_PT
dc.titleA structural road map to unveil basal body composition and assemblypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleControl of Centriole Structure And Number
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBIA-BCM%2F105602%2F2008/PT
oaire.awardURIinfo:eu-repo/grantAgreement/EC/FP7/261344/EU
oaire.citation.endPage521pt_PT
oaire.citation.issue3pt_PT
oaire.citation.startPage519pt_PT
oaire.citation.titleEMBO Journalpt_PT
oaire.citation.volume31pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStreamFP7
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameEuropean Commission
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublicationfb2b2147-605d-4317-85e3-894cad34c70c
relation.isProjectOfPublication0faa6bb2-99b3-4582-9b24-873d528eceb3
relation.isProjectOfPublication.latestForDiscovery0faa6bb2-99b3-4582-9b24-873d528eceb3

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