Publication
Maintaining centrosomes and cilia
| dc.contributor.author | Werner, Sascha | |
| dc.contributor.author | Pimenta-Marques, Ana | |
| dc.contributor.author | Bettencourt-Dias, Mónica | |
| dc.date.accessioned | 2017-11-21T17:10:58Z | |
| dc.date.available | 2018-11-01T01:30:09Z | |
| dc.date.issued | 2017-11-15 | |
| dc.description | The deposited item is a review and has been submitted to peer review. This publication hasn't any creative commons license associated. There is no public supplementary material available for this publication. | pt_PT |
| dc.description.abstract | Centrosomes and cilia are present in organisms from all branches of the eukaryotic tree of life. These structures are composed of microtubules and various other proteins, and are required for a plethora of cell processes such as structuring the cytoskeleton, sensing the environment, and motility. Deregulation of centrosome and cilium components leads to a wide range of diseases, some of which are incompatible with life. Centrosomes and cilia are thought to be very stable and can persist over long periods of time. However, these structures can disappear in certain developmental stages and diseases. Moreover, some centrosome and cilia components are quite dynamic. While a large body of knowledge has been produced regarding the biogenesis of these structures, little is known about how they are maintained. In this Review, we propose the existence of specific centrosome and cilia maintenance programs, which are regulated during development and homeostasis, and when deregulated can lead to disease. | pt_PT |
| dc.description.sponsorship | Fundação para a Ciência e a Tecnologia grants: (SFRH/BPD/79680/2011, SFRH/BD/52176/2013); ERC grant: (ERC-2015-CoG - 683258_CentrioleBirthDeath). | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Maintaining centrosomes and cilia Sascha Werner, Ana Pimenta-Marques, Mónica Bettencourt-Dias J Cell Sci 2017 130: 3789-3800; doi: 10.1242/jcs.203505 | pt_PT |
| dc.identifier.doi | 10.1242/jcs.203505 | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.7/808 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Company of Biologists | pt_PT |
| dc.relation | DYNAMICS AND MAINTENANCE OF CILIA COMPONENTS | |
| dc.relation | Mechanism of centriole inheritance and maintenance | |
| dc.relation.publisherversion | http://jcs.biologists.org/content/130/22/3789.long | pt_PT |
| dc.subject | Centrosomes | pt_PT |
| dc.subject | Cilia | pt_PT |
| dc.subject | Ciliopathies | pt_PT |
| dc.subject | Maintenance | pt_PT |
| dc.title | Maintaining centrosomes and cilia | pt_PT |
| dc.type | review | |
| dspace.entity.type | Publication | |
| oaire.awardTitle | DYNAMICS AND MAINTENANCE OF CILIA COMPONENTS | |
| oaire.awardTitle | Mechanism of centriole inheritance and maintenance | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F79680%2F2011/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F52176%2F2013/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/EC/H2020/683258/EU | |
| oaire.citation.endPage | 3800 | pt_PT |
| oaire.citation.issue | 22 | pt_PT |
| oaire.citation.startPage | 3789 | pt_PT |
| oaire.citation.title | Journal of Cell Science | pt_PT |
| oaire.citation.volume | 130 | pt_PT |
| oaire.fundingStream | SFRH | |
| oaire.fundingStream | H2020 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100008530 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | European Commission | |
| rcaap.embargofct | The deposited article has 12 months of embargo period in terms of access, because of the journal's policies and the publisher's copyright policy, which require a period of embargo of 12months after the date of release of the publication. | pt_PT |
| rcaap.rights | embargoedAccess | pt_PT |
| rcaap.type | review | pt_PT |
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