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Primary sex determination of placental mammals: a modelling study uncovers dynamical developmental constraints in the formation of Sertoli and granulosa cells
| Nome: | Descrição: | Tamanho: | Formato: | |
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| artigo principal | 1.24 MB | Adobe PDF | ||
| material suplementar | 821.66 KB | Adobe PDF |
Autores
Orientador(es)
Resumo(s)
Primary sex determination in placental mammals is a very well studied developmental process. Here, we aim to investigate the currently established scenario and to assess its adequacy to fully recover the observed phenotypes, in the wild type and perturbed situations. Computational modelling allows clarifying network dynamics, elucidating crucial temporal constrains as well as interplay between core regulatory modules.
Descrição
Palavras-chave
Placental mammals Primary sex determination Gene regulatory network Logical modelling
Contexto Educativo
Citação
Sánchez, L., Chaouiya, C. (2016). Primary sex determination of placental mammals: a modelling study uncovers dynamical developmental constraints in the formation of Sertoli and granulosa cells. BMC Systems Biology, 10, 37.
Editora
BioMed Central