Primary sex determination of placental mammals: a modelling study uncovers dynamical developmental constraints in the formation of Sertoli and granulosa cells

Sánchez, Lucas; Chaouiya, Claudine

http://hdl.handle.net/10400.7/630

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Authors

Sánchez, Lucas

Chaouiya, Claudine

Abstract(s)

Primary sex determination in placental mammals is a very well studied developmental process. Here, we aim to investigate the currently established scenario and to assess its adequacy to fully recover the observed phenotypes, in the wild type and perturbed situations. Computational modelling allows clarifying network dynamics, elucidating crucial temporal constrains as well as interplay between core regulatory modules.

Keywords

Placental mammals Primary sex determination Gene regulatory network Logical modelling

URI

http://hdl.handle.net/10400.7/630

Citation

Sánchez, L., Chaouiya, C. (2016). Primary sex determination of placental mammals: a modelling study uncovers dynamical developmental constraints in the formation of Sertoli and granulosa cells. BMC Systems Biology, 10, 37.