How Inflammation Impinges on NAFLD: A Role for Kupffer Cells

Duarte, Nádia; Coelho, Inês C.; Patarrão, Rita S.; Almeida, Joana I.; Penha-Gonçalves, Carlos; Macedo, M. Paula

Publication

How Inflammation Impinges on NAFLD: A Role for Kupffer Cells

2015-03-05Journal article

dc.contributor.author	Duarte, Nádia
dc.contributor.author	Coelho, Inês C.
dc.contributor.author	Patarrão, Rita S.
dc.contributor.author	Almeida, Joana I.
dc.contributor.author	Penha-Gonçalves, Carlos
dc.contributor.author	Macedo, M. Paula
dc.date.accessioned	2016-03-01T15:23:45Z
dc.date.available	2016-03-01T15:23:45Z
dc.date.issued	2015-03-05
dc.description	This deposit is composed by the main article, and it hasn't any supplementary materials associated.
dc.description	This deposit is composed by a publication in which the IGC's authors have had the role of collaboration (it's a collaboration publication). This type of deposit in ARCA is in restrictedAccess (it can't be in open access to the public), and can only be accessed by two ways: either by requesting a legal copy from the author (the email contact present in this deposit) or by visiting the following link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450298/	pt_PT
dc.description.abstract	Nonalcoholic fatty liver disease (NAFLD) is rapidly becoming the most prevalent cause of liver disease worldwide and afflicts adults and children as currently associated with obesity and insulin resistance. Even though lately some advances have been made to elucidate the mechanism and causes of the disease much remains unknown about NAFLD. The aim of this paper is to discuss the present knowledge regarding the pathogenesis of the disease aiming at the initial steps of NAFLD development, when inflammation impinges on fat liver deposition. At this stage, the Kupffer cells attain a prominent role. This knowledge becomes subsequently relevant for the development of future diagnostic, prevention, and therapeutic options for the management of NAFLD.	pt_PT
dc.description.sponsorship	FCT, Portuguese Diabetes Society (SPD).	pt_PT
dc.identifier.citation	Nádia Duarte, Inês C. Coelho, Rita S. Patarrão, Joana I. Almeida, Carlos Penha-Gonçalves, and M. Paula Macedo, “How Inflammation Impinges on NAFLD: A Role for Kupffer Cells,” BioMed Research International, vol. 2015, Article ID 984578, 11 pages, 2015. doi:10.1155/2015/984578	pt_PT
dc.identifier.doi	10.1155/2015/984578	pt_PT
dc.identifier.uri	http://hdl.handle.net/10400.7/554
dc.language.iso	eng	pt_PT
dc.peerreviewed	yes	pt_PT
dc.publisher	Hindawi Publishing Corporation	pt_PT
dc.relation	Insulin Clearance (Dys)Regulation: clarifying the mist.
dc.relation	CD26/DPP4 in Fatty Liver Disease progression: inflammation impinges on dysmetabolism.
dc.relation.publisherversion	http://www.hindawi.com/journals/bmri/2015/984578/	pt_PT
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	pt_PT
dc.subject	Inflammation	pt_PT
dc.subject	Kupffer Cells	pt_PT
dc.title	How Inflammation Impinges on NAFLD: A Role for Kupffer Cells	pt_PT
dc.type	journal article
dspace.entity.type	Publication
oaire.awardTitle	Insulin Clearance (Dys)Regulation: clarifying the mist.
oaire.awardTitle	CD26/DPP4 in Fatty Liver Disease progression: inflammation impinges on dysmetabolism.
oaire.awardURI	info:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FDTP-EPI%2F0207%2F2012/PT
oaire.awardURI	info:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBIM-MET%2F0486%2F2012/PT
oaire.citation.endPage	11	pt_PT
oaire.citation.startPage	1	pt_PT
oaire.citation.title	BioMed Research International	pt_PT
oaire.citation.volume	2015	pt_PT
oaire.fundingStream	3599-PPCDT
oaire.fundingStream	3599-PPCDT
project.funder.identifier	http://doi.org/10.13039/501100001871
project.funder.identifier	http://doi.org/10.13039/501100001871
project.funder.name	Fundação para a Ciência e a Tecnologia
project.funder.name	Fundação para a Ciência e a Tecnologia
rcaap.rights	restrictedAccess	pt_PT
rcaap.type	article	pt_PT
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