dc.contributor.author	Domingos, Ana I
dc.contributor.author	Sordillo, Aylesse
dc.contributor.author	Dietrich, Marcelo O
dc.contributor.author	Liu, Zhong-Wu
dc.contributor.author	Tellez, Luis A
dc.contributor.author	Vaynshteyn, Jake
dc.contributor.author	Ferreira, Jozelia G
dc.contributor.author	Ekstrand, Mats I
dc.contributor.author	Horvath, Tamas L
dc.contributor.author	de Araujo, Ivan E
dc.contributor.author	Friedman, Jeffrey M
dc.date.accessioned	2016-05-05T09:27:16Z
dc.date.available	2016-05-05T09:27:16Z
dc.date.issued	2013-12-31
dc.description.abstract	Sugars that contain glucose, such as sucrose, are generally preferred to artificial sweeteners owing to their post-ingestive rewarding effect, which elevates striatal dopamine (DA) release. While the post-ingestive rewarding effect, which artificial sweeteners do not have, signals the nutrient value of sugar and influences food preference, the neural circuitry that mediates the rewarding effect of glucose is unknown. In this study, we show that optogenetic activation of melanin-concentrating hormone (MCH) neurons during intake of the artificial sweetener sucralose increases striatal dopamine levels and inverts the normal preference for sucrose vs sucralose. Conversely, animals with ablation of MCH neurons no longer prefer sucrose to sucralose and show reduced striatal DA release upon sucrose ingestion. We further show that MCH neurons project to reward areas and are required for the post-ingestive rewarding effect of sucrose in sweet-blind Trpm5(-/-) mice. These studies identify an essential component of the neural pathways linking nutrient sensing and food reward. DOI: http://dx.doi.org/10.7554/eLife.01462.001.	pt_PT
dc.description.sponsorship	JPB Foundation; The Klarman Family Foundation for Eating Disorders; The Rockefeller Foundation; CNPq (Brazil); FCT; National Institutes of Health grants: (DC009997, DK085579, DP1 DK006850).	pt_PT
dc.identifier.citation	eLife 2013;2:e01462	pt_PT
dc.identifier.doi	10.7554/eLife.01462	pt_PT
dc.identifier.uri	http://hdl.handle.net/10400.7/597
dc.language.iso	eng	pt_PT
dc.peerreviewed	yes	pt_PT
dc.publisher	Elife Sciences Publications	pt_PT
dc.relation.publisherversion	https://elifesciences.org/content/2/e01462/article-info	pt_PT
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	pt_PT
dc.subject	feeding behavior	pt_PT
dc.subject	metabolism	pt_PT
dc.subject	neuronal circuits	pt_PT
dc.subject	nutrient	pt_PT
dc.subject	obesity	pt_PT
dc.subject	optogenetics	pt_PT
dc.title	Hypothalamic melanin concentrating hormone neurons communicate the nutrient value of sugar	pt_PT
dc.type	journal article
dspace.entity.type	Publication
oaire.citation.endPage	15	pt_PT
oaire.citation.startPage	1	pt_PT
oaire.citation.title	eLIFE	pt_PT
oaire.citation.volume	2	pt_PT
rcaap.rights	openAccess	pt_PT
rcaap.type	article	pt_PT

Hypothalamic melanin concentrating hormone neurons communicate the nutrient value of sugar

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