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Broadened T-cell Repertoire Diversity in ivIg-treated SLE Patients is Also Related to the Individual Status of Regulatory T-cells

2012-10-14Journal article Open access
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dc.contributor.authorCosta, Nuno
dc.contributor.authorPires, Ana E.
dc.contributor.authorGabriel, Ana M.
dc.contributor.authorGoulart, Luiz F.
dc.contributor.authorPereira, Clara
dc.contributor.authorLeal, Bárbara
dc.contributor.authorQueiros, Ana C.
dc.contributor.authorChaara, Wahiba
dc.contributor.authorMoraes-Fontes, Maria F.
dc.contributor.authorVasconcelos, Carlos
dc.contributor.authorFerreira, Carlos
dc.contributor.authorMartins, Jorge
dc.contributor.authorBastos, Marina
dc.contributor.authorSantos, Maria J.
dc.contributor.authorPereira, Maria A.
dc.contributor.authorMartins, Berta
dc.contributor.authorLima, Margarida
dc.contributor.authorJoão, Cristina
dc.contributor.authorSix, Adrien
dc.contributor.authorDemengeot, Jocelyne
dc.contributor.authorFesel, Constantin
dc.date.accessioned2016-07-05T12:00:12Z
dc.date.available2016-07-05T12:00:12Z
dc.date.issued2012-10-14
dc.description.abstractIntravenous IgG (ivIg) is a therapeutic alternative for lupus erythematosus, the mechanism of which remains to be fully understood. Here we investigated whether ivIg affects two established sub-phenotypes of SLE, namely relative oligoclonality of circulating T-cells and reduced activity of CD4 + Foxp3+ regulatory T-cells (Tregs) reflected by lower CD25 surface density.pt_PT
dc.description.sponsorshipOctapharma research funding; Fundação para a Ciência e a Tecnologia postdoctoral fellowships: (SFRH/BPD/20806/2004, SFRH/BPD/34648/2007); FCT Programa Pessoa travel grant.pt_PT
dc.identifier.citationCosta, N et al. J Clin Immunol (2013) 33: 349. doi:10.1007/s10875-012-9816-7pt_PT
dc.identifier.doi10.1007/s10875-012-9816-7pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/676
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Verlagpt_PT
dc.relation.publisherversionhttp://link.springer.com/article/10.1007%2Fs10875-012-9816-7pt_PT
dc.subjectAdultpt_PT
dc.subjectForkhead Transcription Factorspt_PT
dc.subjectHumanspt_PT
dc.subjectInterleukin-2 Receptor alpha Subunitpt_PT
dc.subjectLongitudinal Studiespt_PT
dc.subjectLupus Erythematosus, Systemicpt_PT
dc.subjectMiddle Agedpt_PT
dc.subjectReceptors, Antigen, T-Cell, alpha-betapt_PT
dc.subjectT-Lymphocyte Subsetspt_PT
dc.subjectT-Lymphocytes, Regulatorypt_PT
dc.subjectYoung Adultpt_PT
dc.subjectImmunoglobulins, Intravenouspt_PT
dc.titleBroadened T-cell Repertoire Diversity in ivIg-treated SLE Patients is Also Related to the Individual Status of Regulatory T-cellspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage360pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage349pt_PT
oaire.citation.titleJournal of Clinical Immunologypt_PT
oaire.citation.volume33pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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