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Author Correction: Genome-wide analysis of multi- and extensively drug-resistant Mycobacterium tuberculosis

2018-05Journal article Restricted access
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dc.contributor.authorColl, Francesc
dc.contributor.authorPhelan, Jody
dc.contributor.authorHill-Cawthorne, Grant A.
dc.contributor.authorNair, Mridul B.
dc.contributor.authorMallard, Kim
dc.contributor.authorAli, Shahjahan
dc.contributor.authorAbdallah, Abdallah M.
dc.contributor.authorAlghamdi, Saad
dc.contributor.authorAlsomali, Mona
dc.contributor.authorAhmed, Abdallah O.
dc.contributor.authorPortelli, Stephanie
dc.contributor.authorOppong, Yaa
dc.contributor.authorAlves, Adriana
dc.contributor.authorBessa, Theolis Barbosa
dc.contributor.authorCampino, Susana
dc.contributor.authorCaws, Maxine
dc.contributor.authorChatterjee, Anirvan
dc.contributor.authorCrampin, Amelia C.
dc.contributor.authorDheda, Keertan
dc.contributor.authorFurnham, Nicholas
dc.contributor.authorGlynn, Judith R.
dc.contributor.authorGrandjean, Louis
dc.contributor.authorHa, Dang Minh
dc.contributor.authorHasan, Rumina
dc.contributor.authorHasan, Zahra
dc.contributor.authorHibberd, Martin L.
dc.contributor.authorJoloba, Moses
dc.contributor.authorJones-López, Edward C.
dc.contributor.authorMatsumoto, Tomoshige
dc.contributor.authorMiranda, Anabela
dc.contributor.authorMoore, David J.
dc.contributor.authorMocillo, Nora
dc.contributor.authorPanaiotov, Stefan
dc.contributor.authorParkhill, Julian
dc.contributor.authorPenha, Carlos
dc.contributor.authorPerdigão, João
dc.contributor.authorPortugal, Isabel
dc.contributor.authorRchiad, Zineb
dc.contributor.authorRobledo, Jaime
dc.contributor.authorSheen, Patricia
dc.contributor.authorShesha, Nashwa Talaat
dc.contributor.authorSirgel, Frik A.
dc.contributor.authorSola, Christophe
dc.contributor.authorSousa, Erivelton Oliveira
dc.contributor.authorStreicher, Elizabeth M.
dc.contributor.authorVan Helden, Paul
dc.contributor.authorViveiros, Miguel
dc.contributor.authorWarren, Robert M.
dc.contributor.authorMcNerney, Ruth
dc.contributor.authorPain, Arnab
dc.contributor.authorClark, Taane G.
dc.date.accessioned2018-05-23T12:27:59Z
dc.date.available2018-05-23T12:27:59Z
dc.date.issued2018-05
dc.descriptionThis deposit is composed by a publication in which the IGC's authors have had the role of collaboration (it's a collaboration publication). This type of deposit in ARCA is in restrictedAccess (it can't be in open access to the public), and can only be accessed by two ways: either by requesting a legal copy from the author (the email contact present in this deposit) or by visiting the following link: https://www.nature.com/articles/s41588-018-0074-3pt_PT
dc.descriptionThis publication hasn't any creative commons license associated.pt_PT
dc.descriptionThis deposit is composed simultaneously by the original published article and also by the "correction" for the published article (erratum). The link for the original article: https://www.nature.com/articles/s41588-017-0029-0#Ack1pt_PT
dc.descriptionThis deposit is composed by the main article plus the supplementary materials of the publication.pt_PT
dc.description.abstractIn the version of this article initially published, the URL listed for TubercuList was incorrect. The correct URL is https://mycobrowser.epfl.ch/. The error has been corrected in the HTML and PDF versions of the article.pt_PT
dc.description.abstractTo characterize the genetic determinants of resistance to antituberculosis drugs, we performed a genome-wide association study (GWAS) of 6,465 Mycobacterium tuberculosis clinical isolates from more than 30 countries. A GWAS approach within a mixed-regression framework was followed by a phylogenetics-based test for independent mutations. In addition to mutations in established and recently described resistance-associated genes, novel mutations were discovered for resistance to cycloserine, ethionamide and para-aminosalicylic acid. The capacity to detect mutations associated with resistance to ethionamide, pyrazinamide, capreomycin, cycloserine and para-aminosalicylic acid was enhanced by inclusion of insertions and deletions. Odds ratios for mutations within candidate genes were found to reflect levels of resistance. New epistatic relationships between candidate drug-resistance-associated genes were identified. Findings also suggest the involvement of efflux pumps (drrA and Rv2688c) in the emergence of resistance. This study will inform the design of new diagnostic tests and expedite the investigation of resistance and compensatory epistatic mechanisms.pt_PT
dc.description.sponsorshipThe project was supported by the KAUST faculty baseline research fund (BAS/1/1020-01-01) to A.P. The authors wish to thank members of the KAUST Bioscience Core laboratory who sequenced samples. We thank the Wellcome Trust Sanger Institute core and pathogen sequencing and informatics teams who were involved in the Malawi and Uganda studies. The work was funded in part by the Wellcome Trust (grant numbers WT096249/Z/11/B, WT088559MA, WT081814/Z/06/Z and WT098051) and the Wellcome Trust–Burroughs Wellcome Fund Infectious Diseases Initiative grant (number 063410/ABC/00/Z). F.C. was the recipient of a Bloomsbury College PhD Studentship and was supported by the Wellcome Trust (201344/Z/16/Z); J. Perdigão received a Fundação para a Ciência e a Tecnologia (Portugal) postdoctoral fellowship fund (SFRH/BPD/95406/2013). The Calouste Gulbenkian Foundation, the Institute Gulbenkian in Lisbon and the European Society of Clinical Microbiology and Infectious Diseases supported the research of C.P., J. Perdigão, I.P. and M.V. J. Phelan is funded by a BBSRC PhD studentship. T.G.C. is funded by the Medical Research Council UK (grant numbers MR/K000551/1, MR/M01360X/1, MR/N010469/1 and MC_PC_15103). N.F. is funded by the Medical Research Council UK (grant number MR/K020420/1). T.M. is supported by the Ministry of Health, Labor and Welfare of Japan (H21-Shinkou-Ippan-008 and H24-Shinkou-Ippan-010).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationColl, F. et al. Author Correction: Genome-wide analysis of multi- and extensively drug-resistant Mycobacterium tuberculosis. Nat. Genet. (2018). doi:10.1038/s41588-018-0074-3pt_PT
dc.identifier.doi10.1038/s41588-018-0074-3pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/879
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherNature Publishing Grouppt_PT
dc.relationBAS/1/1020-01-01pt_PT
dc.relationMR/K000551/1pt_PT
dc.relationMR/M01360X/1pt_PT
dc.relationMR/N010469/1pt_PT
dc.relationMC_PC_15103pt_PT
dc.relationMR/K020420/1pt_PT
dc.relationH21-Shinkou-Ippan-008pt_PT
dc.relationH24-Shinkou-Ippan-010pt_PT
dc.relation.publisherversionhttps://www.nature.com/articles/s41588-018-0074-3pt_PT
dc.subjectGenome-wide association studiespt_PT
dc.subjectMicrobial geneticspt_PT
dc.subjectTuberculosispt_PT
dc.titleAuthor Correction: Genome-wide analysis of multi- and extensively drug-resistant Mycobacterium tuberculosispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/WT/Populations and Public Health/096249
oaire.awardURIinfo:eu-repo/grantAgreement/WT/Populations and Public Health/088559
oaire.awardURIinfo:eu-repo/grantAgreement/WT//081814
oaire.awardURIinfo:eu-repo/grantAgreement/WT/Molecules, Genes and Cells/098051
oaire.awardURIinfo:eu-repo/grantAgreement/WT/Populations and Public Health/063410
oaire.awardURIinfo:eu-repo/grantAgreement/WT/Genetic & Molecular Sciences/201344
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F95406%2F2013/PT
oaire.citation.endPage764pt_PT
oaire.citation.issue5pt_PT
oaire.citation.startPage764pt_PT
oaire.citation.titleNature Geneticspt_PT
oaire.citation.volume50pt_PT
oaire.fundingStreamPopulations and Public Health
oaire.fundingStreamPopulations and Public Health
oaire.fundingStreamMolecules, Genes and Cells
oaire.fundingStreamPopulations and Public Health
oaire.fundingStreamGenetic & Molecular Sciences
oaire.fundingStreamSFRH
project.funder.identifierhttp://doi.org/10.13039/100010269
project.funder.identifierhttp://doi.org/10.13039/100010269
project.funder.identifierhttp://doi.org/10.13039/100010269
project.funder.identifierhttp://doi.org/10.13039/100010269
project.funder.identifierhttp://doi.org/10.13039/100010269
project.funder.identifierhttp://doi.org/10.13039/100010269
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameWellcome Trust
project.funder.nameWellcome Trust
project.funder.nameWellcome Trust
project.funder.nameWellcome Trust
project.funder.nameWellcome Trust
project.funder.nameWellcome Trust
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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relation.isProjectOfPublication793634e1-0551-4701-b1a4-554eeab4fae1
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relation.isProjectOfPublication.latestForDiscovery5bfbf773-d3d7-4e48-ad84-19af4dea752b

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