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Manipulation of the Quorum Sensing Signal AI-2 Affects the Antibiotic-Treated Gut Microbiota

2015-03-24Journal article Open access
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dc.contributor.authorThompson, Jessica Ann
dc.contributor.authorOliveira, Rita Almeida
dc.contributor.authorDjukovic, Ana
dc.contributor.authorUbeda, Carles
dc.contributor.authorXavier, Karina Bivar
dc.date.accessioned2017-05-29T13:54:36Z
dc.date.available2017-05-29T13:54:36Z
dc.date.issued2015-03-24
dc.descriptionThe uploaded pdf article contains attached the supplementary files.pt_PT
dc.description.abstractThe mammalian gut microbiota harbors a diverse ecosystem where hundreds of bacterial species interact with each other and their host. Given that bacteria use signals to communicate and regulate group behaviors (quorum sensing), we asked whether such communication between different commensal species can influence the interactions occurring in this environment. We engineered the enteric bacterium, Escherichia coli, to manipulate the levels of the interspecies quorum sensing signal, autoinducer-2 (AI-2), in the mouse intestine and investigated the effect upon antibiotic-induced gut microbiota dysbiosis. E. coli that increased intestinal AI-2 levels altered the composition of the antibiotic-treated gut microbiota, favoring the expansion of the Firmicutes phylum. This significantly increased the Firmicutes/Bacteroidetes ratio, to oppose the strong effect of the antibiotic, which had almost cleared the Firmicutes. This demonstrates that AI-2 levels influence the abundance of the major phyla of the gut microbiota, the balance of which is known to influence human health.pt_PT
dc.description.sponsorshipHoward Hughes Medical Institute - International Early Career Scientist grant: (HHMI 55007436); Ministerio de Ciencia e Innovacion grant: (MICINN; SAF2011-2945).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJessica Ann Thompson, Rita Almeida Oliveira, Ana Djukovic, Carles Ubeda, Karina Bivar Xavier, Manipulation of the Quorum Sensing Signal AI-2 Affects the Antibiotic-Treated Gut Microbiota, Cell Reports, Volume 10, Issue 11, 24 March 2015, Pages 1861-1871, ISSN 2211-1247, https://doi.org/10.1016/j.celrep.2015.02.049. (http://www.sciencedirect.com/science/article/pii/S2211124715002077)pt_PT
dc.identifier.doi10.1016/j.celrep.2015.02.049pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/762
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationHHMI 55007436pt_PT
dc.relationAdaptation of commensal bacteria to the mammalian gut
dc.relationMICINN SAF2011-2945pt_PT
dc.relationROLE OF THE MICROBIOTA IN THE DEFENSE AGAINST ANTIBIOTIC RESISTANT PATHOGENS
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S2211124715002077pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectAnimalspt_PT
dc.subjectAnti-Bacterial Agentspt_PT
dc.subjectBacteroidetespt_PT
dc.subjectEscherichia colipt_PT
dc.subjectHomoserinept_PT
dc.subjectIntestinespt_PT
dc.subjectLactonespt_PT
dc.subjectMalept_PT
dc.subjectMicept_PT
dc.subjectMice, Inbred C57BLpt_PT
dc.subjectMicrobiotapt_PT
dc.subjectStaphylococcaceaept_PT
dc.subjectStreptomycinpt_PT
dc.subjectQuorum Sensingpt_PT
dc.titleManipulation of the Quorum Sensing Signal AI-2 Affects the Antibiotic-Treated Gut Microbiotapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAdaptation of commensal bacteria to the mammalian gut
oaire.awardTitleROLE OF THE MICROBIOTA IN THE DEFENSE AGAINST ANTIBIOTIC RESISTANT PATHOGENS
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBIA-EVF%2F118075%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/RECI%2FIMI-IMU%2F0038%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/EC/FP7/293894/EU
oaire.citation.endPage1871pt_PT
oaire.citation.issue11pt_PT
oaire.citation.startPage1861pt_PT
oaire.citation.titleCell Reportspt_PT
oaire.citation.volume10pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
oaire.fundingStreamFP7
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameEuropean Commission
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication8a096e46-5521-429a-b9e8-8a7901fe8b30
relation.isProjectOfPublication1470c3e4-1d23-40cc-9500-9f8843b0e35d
relation.isProjectOfPublication807b1dc0-0af3-4e09-9142-0e8cb568ac76
relation.isProjectOfPublication.latestForDiscovery807b1dc0-0af3-4e09-9142-0e8cb568ac76

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