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Revisiting the role of the mother centriole in centriole biogenesis

2007-05-18Journal article Open access
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dc.contributor.authorRodrigues-Martins, A
dc.contributor.authorRiparbelli, M
dc.contributor.authorCallaini, G
dc.contributor.authorGlover, D M
dc.contributor.authorBettencourt-Dias, M
dc.date.accessioned2020-04-28T16:04:57Z
dc.date.available2020-04-28T16:04:57Z
dc.date.issued2007-05-18
dc.description.abstractCentrioles duplicate once in each cell division cycle through so-called templated or canonical duplication. SAK, also called PLK4 (SAK/PLK4), a kinase implicated in tumor development, is an upstream regulator of canonical biogenesis necessary for centriole formation. We found that overexpression of SAK/PLK4 could induce amplification of centrioles in Drosophila embryos and their de novo formation in unfertilized eggs. Both processes required the activity of DSAS-6 and DSAS-4, two molecules required for canonical duplication. Thus, centriole biogenesis is a template-free self-assembly process triggered and regulated by molecules that ordinarily associate with the existing centriole. The mother centriole is not a bona fide template but a platform for a set of regulatory molecules that catalyzes and regulates daughter centriole assembly.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1126/science.1142950pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/955
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectAnimalspt_PT
dc.subjectAnimals, Genetically Modifiedpt_PT
dc.subjectCentriolespt_PT
dc.subjectCentrosomept_PT
dc.subjectDrosophilapt_PT
dc.subjectDrosophila Proteinspt_PT
dc.subjectEmbryo, Nonmammalianpt_PT
dc.subjectEmbryonic Developmentpt_PT
dc.subjectFemalept_PT
dc.subjectMitosispt_PT
dc.subjectOocytespt_PT
dc.titleRevisiting the role of the mother centriole in centriole biogenesispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1050pt_PT
oaire.citation.issue5827pt_PT
oaire.citation.startPage1046-50pt_PT
oaire.citation.titleScience (New York, N.Y.)pt_PT
oaire.citation.volume316pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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