Basic properties of epigenetic systems: lessons from the centromere

Gómez-Rodríguez, Mariluz; Jansen, Lars ET

http://hdl.handle.net/10400.7/626

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Authors

Gómez-Rodríguez, Mariluz

Jansen, Lars ET

Abstract(s)

Chromatin-based epigenetic inheritance cooperates with cis-acting DNA sequence information to propagate gene expression states and chromosome architecture across cell division cycles. Histone proteins and their modifications are central components of epigenetic systems but how, and to what extent, they are propagated is a matter of continued debate. Centromeric nucleosomes, marked by the histone H3 variant CENP-A, are stable across mitotic divisions and are assembled in a locus specific and cell cycle controlled manner. The mechanism of inheritance of this unique chromatin domain has important implications for how general nucleosome transmission is controlled in space and time.

Keywords

Autoantigens Cell Division Centromere Chromatin Chromosomal Proteins, Non-Histone Epigenesis, Genetic Gene Expression Regulation Histones Kinetochores Nucleosomes

URI

http://hdl.handle.net/10400.7/626

Citation

Mariluz Gómez-Rodríguez, Lars ET Jansen, Basic properties of epigenetic systems: lessons from the centromere, Current Opinion in Genetics & Development, Volume 23, Issue 2, April 2013, Pages 219-227, ISSN 0959-437X, http://dx.doi.org/10.1016/j.gde.2012.11.002.