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Basic properties of epigenetic systems: lessons from the centromere

2013-04Journal article Restricted access
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dc.contributor.authorGómez-Rodríguez, Mariluz
dc.contributor.authorJansen, Lars ET
dc.date.accessioned2016-06-07T15:16:09Z
dc.date.available2016-06-08T00:30:08Z
dc.date.issued2013-04
dc.description.abstractChromatin-based epigenetic inheritance cooperates with cis-acting DNA sequence information to propagate gene expression states and chromosome architecture across cell division cycles. Histone proteins and their modifications are central components of epigenetic systems but how, and to what extent, they are propagated is a matter of continued debate. Centromeric nucleosomes, marked by the histone H3 variant CENP-A, are stable across mitotic divisions and are assembled in a locus specific and cell cycle controlled manner. The mechanism of inheritance of this unique chromatin domain has important implications for how general nucleosome transmission is controlled in space and time.pt_PT
dc.description.sponsorshipFCT doctoral fellowship: (SFRH/BD/33567/2008); FCT grants: (BIA-BCM/100557/2008, BIA-PRO/100537/2008); European Commission FP7 Program; EMBO installation grant.pt_PT
dc.identifier.citationMariluz Gómez-Rodríguez, Lars ET Jansen, Basic properties of epigenetic systems: lessons from the centromere, Current Opinion in Genetics & Development, Volume 23, Issue 2, April 2013, Pages 219-227, ISSN 0959-437X, http://dx.doi.org/10.1016/j.gde.2012.11.002.pt_PT
dc.identifier.doi10.1016/j.gde.2012.11.002pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/626
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsivier Science BVpt_PT
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S0959437X12001311pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAutoantigenspt_PT
dc.subjectCell Divisionpt_PT
dc.subjectCentromerept_PT
dc.subjectChromatinpt_PT
dc.subjectChromosomal Proteins, Non-Histonept_PT
dc.subjectEpigenesis, Geneticpt_PT
dc.subjectGene Expression Regulationpt_PT
dc.subjectHistonespt_PT
dc.subjectKinetochorespt_PT
dc.subjectNucleosomespt_PT
dc.titleBasic properties of epigenetic systems: lessons from the centromerept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage227pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage219pt_PT
oaire.citation.titleCurrent Opinion in Genetics & Developmentpt_PT
oaire.citation.volume23pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT

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