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Genetics. Sowing the seeds of centromeres.
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Autores
Orientador(es)
Resumo(s)
The centromere is a chromatin-based platform that accumulates microtubule-binding proteins that drive chromosome segregation during cell division. Despite their size (on the order of megabases of DNA in mammals) and conserved role, centromeres have the remarkable capacity to leave their usual comfort zone and to reform at a new chromosomal site (1). Although found rarely, these so-called neocentromeres are by most measures bona fide and segregate chromosomes with high fidelity. What accounts for this nomadic behavior?
Descrição
Palavras-chave
Animals Centromere Drosophila Histones
Contexto Educativo
Citação
Jansen, L. E. T. (2012). Genetics. Sowing the seeds of centromeres. Science, 335(6066), 299–300.
Editora
American Association for the Advancement of Science