Genetics. Sowing the seeds of centromeres.

Jansen, L. E. T.

http://hdl.handle.net/10400.7/615

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Authors

Jansen, L. E. T.

Abstract(s)

The centromere is a chromatin-based platform that accumulates microtubule-binding proteins that drive chromosome segregation during cell division. Despite their size (on the order of megabases of DNA in mammals) and conserved role, centromeres have the remarkable capacity to leave their usual comfort zone and to reform at a new chromosomal site (1). Although found rarely, these so-called neocentromeres are by most measures bona fide and segregate chromosomes with high fidelity. What accounts for this nomadic behavior?

Keywords

Animals Centromere Drosophila Histones

URI

http://hdl.handle.net/10400.7/615

Citation

Jansen, L. E. T. (2012). Genetics. Sowing the seeds of centromeres. Science, 335(6066), 299–300.

Publisher

American Association for the Advancement of Science

DOI

10.1126/science.1218162

Collections

EM - Artigos

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