Transcriptomic and metabolomic profiling of ionic liquid stimuli unveils enhanced secondary metabolism in Aspergillus nidulans

Alves, Paula C.; Hartmann, Diego O.; Núñez, Oscar; Martins, Isabel; Gomes, Teresa L.; Garcia, Helga; Galceran, Maria Teresa; Hampson, Richard; Becker, Jörg D.; Silva Pereira, Cristina

http://hdl.handle.net/10400.7/579

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Authors

Galceran, Maria Teresa

Hampson, Richard

Becker, Jörg D.

Silva Pereira, Cristina

Abstract(s)

The inherent potential of filamentous fungi, especially of Ascomycota, for producing diverse bioactive metabolites remains largely silent under standard laboratory culture conditions. Innumerable strategies have been described to trigger their production, one of the simplest being manipulation of the growth media composition. Supplementing media with ionic liquids surprisingly enhanced the diversity of extracellular metabolites generated by penicillia. This finding led us to evaluate the impact of ionic liquids' stimuli on the fungal metabolism in Aspergillus nidulans and how it reflects on the biosynthesis of secondary metabolites (SMs).