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Transcriptomic and metabolomic profiling of ionic liquid stimuli unveils enhanced secondary metabolism in Aspergillus nidulans

2016-04-12Journal article Open access
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dc.contributor.authorAlves, Paula C.
dc.contributor.authorHartmann, Diego O.
dc.contributor.authorNúñez, Oscar
dc.contributor.authorMartins, Isabel
dc.contributor.authorGomes, Teresa L.
dc.contributor.authorGarcia, Helga
dc.contributor.authorGalceran, Maria Teresa
dc.contributor.authorHampson, Richard
dc.contributor.authorBecker, Jörg D.
dc.contributor.authorSilva Pereira, Cristina
dc.date.accessioned2016-04-18T11:45:59Z
dc.date.available2016-04-18T11:45:59Z
dc.date.issued2016-04-12
dc.description.abstractThe inherent potential of filamentous fungi, especially of Ascomycota, for producing diverse bioactive metabolites remains largely silent under standard laboratory culture conditions. Innumerable strategies have been described to trigger their production, one of the simplest being manipulation of the growth media composition. Supplementing media with ionic liquids surprisingly enhanced the diversity of extracellular metabolites generated by penicillia. This finding led us to evaluate the impact of ionic liquids' stimuli on the fungal metabolism in Aspergillus nidulans and how it reflects on the biosynthesis of secondary metabolites (SMs).pt_PT
dc.description.sponsorshipEuropean Research Council grant: (ERC-2014-CoG-647928); Spanish Ministry of Economy and Competitiveness project: (CTQ2012-30836); Agency for Administration of University and Research Grants (Generalitat de Catalunya, Spain) project: (2014 SGR-539); COST Action EXIL – Exchange on Ionic Liquids: (CM1206); FCT fellowships and contract grant: (SFRH/BD/66030/2009, SFRH/BPD/110841/2015, IF/00713/2013).pt_PT
dc.identifier.doi10.1186/s12864-016-2577-6pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/579
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBioMed Centralpt_PT
dc.relationCreating value from bio-wastes: suberin extraction and biotransformation in biocompatible ionic liquids aiming on novel biomaterials and compounds
dc.relation.publisherversionhttp://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-016-2577-6pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAspergillus nidulanspt_PT
dc.subjectMonodictyphenonept_PT
dc.subjectOrsellinic acidpt_PT
dc.subjectSecondary metabolismpt_PT
dc.subjectIonic liquidspt_PT
dc.subjectMetabolomicspt_PT
dc.subjectTranscriptomicspt_PT
dc.titleTranscriptomic and metabolomic profiling of ionic liquid stimuli unveils enhanced secondary metabolism in Aspergillus nidulanspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCreating value from bio-wastes: suberin extraction and biotransformation in biocompatible ionic liquids aiming on novel biomaterials and compounds
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F04551%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FQUI-QUI%2F120982%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FAAC-CLI%2F119100%2F2010/PT
oaire.citation.endPage18pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleBMC Genomicspt_PT
oaire.citation.volume17pt_PT
oaire.fundingStream5876
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublicationf0a3f9cf-be53-424f-ac33-17539df53098
relation.isProjectOfPublication6bd77891-e85a-4d93-9944-3f816a20c697
relation.isProjectOfPublicationfecf2b48-d69e-491d-8718-2060b60a34b6
relation.isProjectOfPublication.latestForDiscoveryf0a3f9cf-be53-424f-ac33-17539df53098

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