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http://hdl.handle.net/10400.7/618| Title: | How two become one: HJURP dimerization drives CENP-A assembly |
| Author: | Bodor, Dani L Jansen, Lars E T |
| Keywords: | Autoantigens Centromere Chromosomal Proteins, Non-Histone DNA-Binding Proteins Humans Nucleosomes Protein Multimerization |
| Issue Date: | 21-Jun-2013 |
| Publisher: | Embo Press |
| Citation: | Bodor, D. L., Jansen, L. E. T. (2013). How two become one: HJURP dimerization drives CENP-A assembly. EMBO J., 32(15), 2090–2092. |
| Abstract: | CENP‐A containing nucleosomes epigenetically specify centromere position on chromosomes. Deposition of CENP‐A into chromatin is mediated by HJURP, a specific CENP‐A chaperone. Paradoxically, HJURP binding sterically prevents dimerization of CENP‐A, which is critical to form functional centromeric nucleosomes. A recent publication in The EMBO Journal (Zasadzińska et al, 2013) demonstrates that HJURP itself dimerizes through a C‐terminal repeat region, which is essential for centromeric assembly of nascent CENP‐A. |
| Peer review: | yes |
| URI: | http://hdl.handle.net/10400.7/618 |
| DOI: | 10.1038/emboj.2013.150 |
| Publisher Version: | http://emboj.embopress.org/content/32/15/2090 |
| Appears in Collections: | EM - Artigos |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Bodor_EMBOJ2013_postprint.pdf | artigo principal | 812,31 kB | Adobe PDF | View/Open |
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