Please use this identifier to cite or link to this item:
http://hdl.handle.net/10400.7/626| Title: | Basic properties of epigenetic systems: lessons from the centromere |
| Author: | Gómez-Rodríguez, Mariluz Jansen, Lars ET |
| Keywords: | Autoantigens Cell Division Centromere Chromatin Chromosomal Proteins, Non-Histone Epigenesis, Genetic Gene Expression Regulation Histones Kinetochores Nucleosomes |
| Issue Date: | Apr-2013 |
| Publisher: | Elsivier Science BV |
| Citation: | Mariluz Gómez-Rodríguez, Lars ET Jansen, Basic properties of epigenetic systems: lessons from the centromere, Current Opinion in Genetics & Development, Volume 23, Issue 2, April 2013, Pages 219-227, ISSN 0959-437X, http://dx.doi.org/10.1016/j.gde.2012.11.002. |
| Abstract: | Chromatin-based epigenetic inheritance cooperates with cis-acting DNA sequence information to propagate gene expression states and chromosome architecture across cell division cycles. Histone proteins and their modifications are central components of epigenetic systems but how, and to what extent, they are propagated is a matter of continued debate. Centromeric nucleosomes, marked by the histone H3 variant CENP-A, are stable across mitotic divisions and are assembled in a locus specific and cell cycle controlled manner. The mechanism of inheritance of this unique chromatin domain has important implications for how general nucleosome transmission is controlled in space and time. |
| Peer review: | yes |
| URI: | http://hdl.handle.net/10400.7/626 |
| DOI: | 10.1016/j.gde.2012.11.002 |
| Publisher Version: | http://www.sciencedirect.com/science/article/pii/S0959437X12001311 |
| Appears in Collections: | EM - Artigos |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| gomez_COGD 2013_postprint.pdf | artigo principal | 629,04 kB | Adobe PDF | View/Open Request a copy |
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
